Abstract Background An ageing population Bumper Accent Piece has resulted in a rise in the number of hip and knee replacement surgeries in the UK.The pre-operative pathway is plagued with issues causing long delays and cancellations.Virtual healthcare technologies have a growing evidence base to help solve these issues.One problem of implementing t
Retinoic acid (RA) was one of the first molecules in the modern era of experimental embryology to be shown capable of generating profound effects on limb development.In this review, we focus on the earliest events of limb development and specifically on the role 131 of RA in establishing the domain of cells that will go on to form the limb itself.A
Abstract Background Papain-like cysteine proteases (PLCPs), a large group of cysteine proteases structurally related to papain, play important roles in plant development, senescence, and defense responses.Papain, the first cysteine protease whose structure was determined by X-ray crystallography, plays a crucial role in protecting papaya from herbi
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by erosive polyarthritis.Beyond joint pathology, RA is associated with neuropsychiatric comorbidity including depression, anxiety, and an increased risk to develop neurodegenerative diseases in later life.Studies investigating the central nervous system (CNS) in preclinical m